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Multiple Sclerosis (MS) Fatigue
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Multiple Sclerosis Symptoms

Fatigue is without any doubt one of the most disabling symptoms for people suffering of MS, and at the same time one of the most common. There are over five different fatigues that are present when dealing with MS.


However, people that suffer from MS are, as any other person, affected by normal fatigue as well. A person suffering from MS must learn to differentiate this fatigue from the others and act accordingly. This type of fatigue is not damaging but tiring – as for any other human being.


As MS can lead to depression and depression to fatigue, it is important to understand that there treatments for depression that are highly effective and efficient. 


When demyelination occurs in the brain as a result of MS, the brain’s neurochemistry is changed. This usually manifests with sleep disturbances, depression, eating disturbances and fatigue. Usually depression appears because of the unusual levels of serotonin in the brain - a neurotransmitter that controls moods. Specific serotonin inhibiting mediations are especially valuable when dealing with depression and the lack of energy coming with it.


Another type of fatigue is neuromuscular fatigue. As the name suggest this presents itself as muscle fatigue. The best treatment for this type of fatigue is rest, as it allows the nerve and muscle affected by the demyelanization to recuperate.


Multiple Sclerosis specific fatigue, lassitude, is a type of fatigue that comes as a sleepiness over the person, even if he or she is rested and had a good night’s sleep.  For this neurochemicals, as amantidine and fluoxetine, are benefic.  A popular agent for managing lassitude has proven to be Modafinil, as it appears to have no specific dependence associated with its use. Other stimulants are known to give dependencies. When using a combination of medicines to treat fatigue, care must be taken not to provoke agitation. Of course, great care must be taken when using sedatives or other sedation medications that are used to treat other Multiple Sclerosis symptoms.

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